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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ITIH4
All Species:
9.09
Human Site:
S446
Identified Species:
25
UniProt:
Q14624
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14624
NP_002209.2
930
103357
S446
R
I
H
E
D
S
D
S
A
L
Q
L
Q
D
F
Chimpanzee
Pan troglodytes
XP_516522
930
103281
S446
R
I
H
E
D
S
D
S
A
L
Q
L
Q
D
F
Rhesus Macaque
Macaca mulatta
XP_001085586
930
102291
S446
R
I
H
E
D
S
D
S
A
L
Q
L
Q
D
F
Dog
Lupus familis
XP_848765
826
91427
R356
D
A
M
L
T
A
V
R
L
L
Q
S
A
N
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q61704
889
99347
K419
V
R
N
A
I
G
G
K
F
P
L
Y
N
L
G
Rat
Rattus norvegicus
Q63416
887
99079
R417
E
N
V
R
N
A
I
R
G
K
F
P
L
Y
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508722
950
105792
L426
Y
E
D
S
D
A
A
L
Q
L
Q
D
F
Y
Q
Chicken
Gallus gallus
XP_414253
886
99843
E416
T
H
V
K
K
A
I
E
G
K
Y
T
L
Y
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_693183
963
108893
K490
I
L
L
D
T
L
A
K
Q
N
D
G
L
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
93.7
70
N.A.
38.8
39.5
N.A.
46.7
38
N.A.
37
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
97
78.7
N.A.
55.8
56.7
N.A.
61.3
57.6
N.A.
54.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
13.3
N.A.
0
0
N.A.
20
0
N.A.
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
6.6
13.3
N.A.
26.6
13.3
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
0
12
0
45
23
0
34
0
0
0
12
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
0
12
12
45
0
34
0
0
0
12
12
0
34
0
% D
% Glu:
12
12
0
34
0
0
0
12
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
12
0
12
0
12
0
34
% F
% Gly:
0
0
0
0
0
12
12
0
23
0
0
12
0
0
12
% G
% His:
0
12
34
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
12
34
0
0
12
0
23
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
12
12
0
0
23
0
23
0
0
0
0
0
% K
% Leu:
0
12
12
12
0
12
0
12
12
56
12
34
34
12
0
% L
% Met:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
12
12
0
12
0
0
0
0
12
0
0
12
12
23
% N
% Pro:
0
0
0
0
0
0
0
0
0
12
0
12
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
23
0
56
0
34
0
23
% Q
% Arg:
34
12
0
12
0
0
0
23
0
0
0
0
0
0
12
% R
% Ser:
0
0
0
12
0
34
0
34
0
0
0
12
0
0
0
% S
% Thr:
12
0
0
0
23
0
0
0
0
0
0
12
0
0
0
% T
% Val:
12
0
23
0
0
0
12
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
12
0
0
0
0
0
0
0
0
0
12
12
0
34
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _